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郑晓峰

郑晓峰,教授,博士生导师。美国宾夕法尼亚州大学博士后研究员,现任北京大学生命科学学院教授。

郑晓峰教授和罗明教授课题组对一个新的NADP(H)结合蛋白(HSCARG) 的结构与功能特征进行了研究。NADP和一氧化氮是两个重要的具有广泛调节功能的信号分子,是否存在连接这两个信号通路的调节蛋白一直是人们关注的问题。

对HSCARG蛋白的晶体结构进行了解析,其最突出的特点是HSCARG能够形成一个不对称的二聚体,该蛋白N端的Rossmann折叠与NADP(H)结合后发生明显的构象变化。

HSCARG是一个新的NADPH sensor蛋白,它是连接细胞氧化还原状态与一氧化氮信号通路的一个关键的蛋白:HSCARG通过感应细胞内NADP(H)浓度的变化,发生构象的变化来发挥其调节功能。

1. Straightening of bulged RNA by the double-stranded RNA-binding domain from the protein kinase PKR,Second International Conference: Proteins that bind RNA , 2001.2

.2. Activation of the protein kinase PKR by small double-stranded RNAs flanked by single-stranded regions.,The 3rd Annual Meeting of the China RNA Society & 1st International RNA Workshop in China , 2003.7

3. Restructuring of the dinucleotide binding fold in a NADP(H) sensor protein,International Symposium on Synchrotron Radiation and Biology , 2007.11

4. 北京生物化学学会2007年年会 , 2007.12

5. Serum presence of preS antigen in chronic hepatitis B: a significant serological marker in HBV prognosis,Advances in Protein Sciences, Hongkong , 2005.12

1. Li, T,T., Guan J., Li, S.Z., Zhang, X.D.,Zheng, X.F.,HSCARG downregulates TNF-induced NF-κB signaling by interacting with USP7 and inhibiting NEMO ubiquitination., Cell Difference & Diseases. , 2014 , 5: e1229.

2. Peng YY, Xu RD,Zheng XF,HSCARG negatively regulates the cellular antiviral RIG-I like receptor signaling pathway by inhibiting TRAF3 ubiquitination via recruiting OTUB1, PLoS Pathogen , 2014 , Accepted

3. Hu B, Li SZ, Zhang XD,Zheng XF,HSCARG, a novel regulator of H2A ubiquitination by downregulating PRC1 ubiquitin E3 ligase activity, is essential for cell proliferation, Nucleic Acid Res , 2014 , Accepted

4. Xiao W, Meng G, Zhao Y, Yuan H, Li T, Peng Y, Zhao Y, Luo M, Zhao, WM, Li Z,Zheng XF,Human SI-CLP aggravates the inflammation of the arthritis and is a potential macrophage inflammatory regulator, Arthritis Rheumatol , 2014 , doi: 10.1002/art.38356

5. Li TT, Guan JH, Huang ZJ, Hu X,Zheng XF,RNF168-mediated H2A neddylation antagonizes its ubiquitination and regulates DNA damage repair, Journal Cell Science , 2014 , Accepted

6. Li G, Qu L, Ma S, Wu Y, J CW,Zheng XF,Structures determination of human Fas Apoptosis Inhibitory Molecule and identification of the critical residues linking the interdomain interaction to the anti-apoptotic activity, Acta crystallgrophy D , 2014 , Accepted

7. Bai, D.M., Zhang, J., Xiao, W.C.,Zheng, X.F,Regulation of the HDM2-p53 pathway by ribosomal protein L6 in response to ribosomal stress., Nucleic Acid Res. , 2014 , 42(3):1799-1811.

8. Zhang JF, Bai DM, Ma XW, Guan JH,Zheng XF,hCINAP is a novel regulator of ribosomal protein-HDM2-p53 pathway by controlling NEDDylation of ribosomal protein S14, Oncogene , 2014 , 33, 246-254. doi: 10.1038/onc.2012.560 ,

9. Meng G, An X, Ye, S, Liu Y, Zhu W, Zhang R,Zheng XF,The crystal structure of LidA, a translocated substrate of the Legionella pneumophila Type IV secretion system, reveals a novel folding, Protein & Cell , 2013 , 4(12):897-900

10. Bai DM, Zhang J, Xiao WC,Zheng XF,Regulation of the HDM2-p53 pathway by ribosomal protein L6 in response to ribosomal stress, Nucleic Acid Res , 2013 , doi: 10.1093/nar/gkt971

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